Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

Keywords

InflammationTLR2BiologyImmunologyTLR4ReceptorCell biology

Affiliated Institutions

Related Publications

Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability

Francesco Colotta , Paola Allavena , Antonio Sica +2 more

Inflammatory conditions in selected organs increase the risk of cancer. An inflammatory component is present also in the microenvironment of tumors that are not epidemiologicall...

2009 Carcinogenesis 2813 citations

Selective Roles for Toll-Like Receptor (TLR)2 and TLR4 in the Regulation of Neutrophil Activation and Life Span

Ian Sabroe , Lynne R. Prince , Elizabeth C. Jones +5 more

Abstract Neutrophil responses to commercial LPS, a dual Toll-like receptor (TLR)2 and TLR4 activator, are regulated by TLR expression, but are amplified by contaminating monocyt...

2003 The Journal of Immunology 339 citations

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Catherine Dostert , Virginie Pétrilli , Robin van Bruggen +3 more

The inhalation of airborne pollutants, such as asbestos or silica, is linked to inflammation of the lung, fibrosis, and lung cancer. How the presence of pathogenic dust is recog...

2008 Science 2616 citations

Lessons Learned to Date on COVID-19 Hyperinflammatory Syndrome: Considerations for Interventions to Mitigate SARS-CoV-2 Viral Infection and Detrimental Hyperinflammation

Marco Cardone , Masahide Yano , Amy S. Rosenberg +1 more

The first case of human transmission of SARS-CoV-2 was reported in China in December 2019. A few months later, this viral infection had spread worldwide and became a pandemic. T...

2020 Frontiers in Immunology 52 citations

The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy

Lionel Apétoh , François Ghiringhelli , Antoine Tesnière +11 more

Summary: For the last four decades, the treatment of cancer has relied on four treatment modalities, namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Mo...

2007 Immunological Reviews 545 citations

Publication Info

Year: 2007
Type: article
Volume: 13
Issue: 7
Pages: 851-856
Citations: 841
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Identification of a key pathway required for the sterile inflammatory response triggered by dying cells

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

841

OpenAlex

Cite This

APA Style

                            
                                
                                    Chun‐Jen Chen, 
                                
                                    Hajime Kono, 
                                
                                    Douglas T. Golenbock
                                
                                et al.
                            
                            (2007). 
                            Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. 
                            Nature Medicine
                            , 13
                            (7)
                            , 851-856.
                            https://doi.org/10.1038/nm1603
                        

Identifiers

DOI: 10.1038/nm1603