Abstract

The mitogen-activated protein kinase (MAPK) pathway is a conserved eukaryotic signaling module that converts receptor signals into various outputs. MAPK is activated through phosphorylation by MAPK kinase (MAPKK), which is first activated by MAPKK kinase (MAPKKK). A genetic selection based on a MAPK pathway in yeast was used to identify a mouse protein kinase (TAK1) distinct from other members of the MAPKKK family. TAK1 was shown to participate in regulation of transcription by transforming growth factor-β (TGF-β). Furthermore, kinase activity of TAK1 was stimulated in response to TGF-β and bone morphogenetic protein. These results suggest that TAK1 functions as a mediator in the signaling pathway of TGF-β superfamily members.

Keywords

MAP kinase kinase kinaseCyclin-dependent kinase 9ASK1Mitogen-activated protein kinase kinaseMAP2K7Cell biologyc-RafMAPK/ERK pathwayProtein kinase ASignal transductionBiologyCyclin-dependent kinase 2Cancer researchKinase

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Publication Info

Year
1995
Type
article
Volume
270
Issue
5244
Pages
2008-2011
Citations
1337
Access
Closed

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Toshihiro Yamaguchi, Kyoko Shirakabe, Hiroshi Shibuyà et al. (1995). Identification of a Member of the MAPKKK Family as a Potential Mediator of TGF-β Signal Transduction. Science , 270 (5244) , 2008-2011. https://doi.org/10.1126/science.270.5244.2008

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DOI
10.1126/science.270.5244.2008