IgA dominates the early neutralizing antibody response to SARS-CoV-2

Delphine Sterlin; Alexis Mathian; Makoto Miyara; Audrey Mohr; François Anna; Laetitia Claër; Paul Quentric; Jehane Fadlallah; Hervé Devilliers; P. Ghillani; Cary Gunn; Rick Hockett; Sasi Mudumba; Amélie Guihot; Charles‐Édouard Luyt; Julien Mayaux; Alexandra Beurton; S. Fourati; Timothée Bruel; Olivier Schwartz; Jean‐Marc Lacorte; Hans Yssel; Christophe Parizot; Karim Dorgham; Pierre Charneau; Zahir Amoura; Guy Gorochov

doi:10.1126/scitranslmed.abd2223

Abstract

Early specific antibody responses against SARS-CoV-2 include IgG, IgM, and IgA, but IgA may neutralize virus and control infection to a larger extent.

Keywords

Neutralizing antibodyAntibody responseAntibodySevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologySars virusImmunologyCoronavirus disease 2019 (COVID-19)MedicineInternal medicineInfectious disease (medical specialty)Disease

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Publication Info

Year: 2020
Type: article
Volume: 13
Issue: 577
Citations: 1089
Access: Closed

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APA Style

                            
                                
                                    Delphine Sterlin, 
                                
                                    Alexis Mathian, 
                                
                                    Makoto Miyara
                                
                                et al.
                            
                            (2020). 
                            IgA dominates the early neutralizing antibody response to SARS-CoV-2. 
                            Science Translational Medicine
                            , 13
                            (577)
                            .
                            https://doi.org/10.1126/scitranslmed.abd2223
                        

Identifiers

DOI: 10.1126/scitranslmed.abd2223