Abstract

Type 1 diabetes is the clinical manifestation of aberrant leukocytic infiltration of the pancreatic islets; it is usually diagnosed only very late in disease progression, after the critical autoimmune phenomena have mostly played out. A noninvasive means of directly monitoring the evolution of islet infiltrates would have important research and clinical applications. We have exploited fluorescence and MRI of long-circulating magnetofluorescent nanoparticles to visualize micro-vascular leakage, as an indicator of inflammation, in pancreata of mouse models of type 1 diabetes ex vivo or in vivo . We could detect the onset and evolution of insulitis in vivo and in real time, permitting us to study the natural history of diabetes in individual animals.

Keywords

InsulitisIsletPancreatic isletsPancreasInflammationIn vivoDiabetes mellitusType 2 diabetesNatural historyMedicineType 1 diabetesEx vivoPathologyImmunologyInternal medicineBiologyEndocrinology

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Publication Info

Year
2004
Type
article
Volume
101
Issue
34
Pages
12634-12639
Citations
180
Access
Closed

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Maria C. Denis, Umar Mahmood, Christophe Benoıst et al. (2004). Imaging inflammation of the pancreatic islets in type 1 diabetes. Proceedings of the National Academy of Sciences , 101 (34) , 12634-12639. https://doi.org/10.1073/pnas.0404307101

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DOI
10.1073/pnas.0404307101