Immunology of COVID-19: Current State of the Science

Nicolas Vabret , Graham J. Britton , Conor Gruber , Nicolas Vabret , Graham J. Britton , Conor Gruber , Samarth Hegde , Joel Kim , Maria Kuksin , Rachel Levantovsky , Louise Malle , Alvaro Moreira , Matthew D. Park , Luisanna Pia , Emma Risson , Miriam Saffern , Bérengère Salomé , Myvizhi Esai Selvan , Matthew P. Spindler , Jessica Tan , Verena van der Heide , Jill Gregory , Konstantina Alexandropoulos , Nina Bhardwaj , Brian D. Brown , Benjamin D. Greenbaum , Zeynep H. Gümüş , Dirk Homann , Amir Horowitz , Alice O. Kamphorst , Maria A. Curotto de Lafaille , Saurabh Mehandru , Miriam Mérad , Robert M. Samstein , Manasi Agrawal , Mark Aleynick , Meriem Belabed , Matthew Brown , María Casanova-Acebes , Jovani Catalan , Monica Centa , Andrew Charap , Andrew Chan , Steven T. Chen , Jonathan H. Chung , Cansu Cimen Bozkus , Evan Cody , Francesca Cossarini , Erica Dalla , Nicolas Fernandez , John A. Grout , Dan Fu Ruan , Pauline Hamon , Étienne Humblin , Divya Jha , Julia Kodysh , Andrew M. Leader , Matthew Lin , Katherine E. Lindblad , Daniel Lozano‐Ojalvo , Gabrielle S. Lubitz , Assaf Magen , Zafar Mahmood , Gustavo Martínez-Delgado , Jaime Mateus-Tique , Elliot Meritt , Chang Moon , Justine Noel , Tim O’Donnell , Miyo Ota , Tamar Plitt , Venu Pothula , Jamie Redes , Ivan Reyes Torres , Mark Roberto , Alfonso R. Sánchez-Paulete , Joan Shang , Alessandra Soares‐Schanoski , Maria Suprun , Michelle Tran , Natalie Vaninov , C. Matthias Wilk , Julio A. Aguirre‐Ghiso , Dusan Bogunovic , Judy H. Cho , Jeremiah J. Faith , Emilie K. Grasset , Peter S. Heeger , Ephraim Kenigsberg , Florian Krammer , Uri Laserson
2020 Immunity 1,755 citations

Abstract

The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected millions of people worldwide, igniting an unprecedented effort from the scientific community to understand the biological underpinning of COVID19 pathophysiology. In this Review, we summarize the current state of knowledge of innate and adaptive immune responses elicited by SARS-CoV-2 infection and the immunological pathways that likely contribute to disease severity and death. We also discuss the rationale and clinical outcome of current therapeutic strategies as well as prospective clinical trials to prevent or treat SARS-CoV-2 infection.

Keywords

Coronavirus disease 2019 (COVID-19)Biology2019-20 coronavirus outbreakSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)VirologyCurrent (fluid)State (computer science)Coronavirus InfectionsImmunologyComputational biologyMedicineComputer scienceOutbreakInfectious disease (medical specialty)PathologyDisease

MeSH Terms

AnimalsBetacoronavirusCOVID-19Coronavirus InfectionsDisease SusceptibilityHumansImmunityInnateImmunologic MemoryInflammationLymphocytesMyeloid CellsPandemicsPneumoniaViralSARS-CoV-2

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Publication Info

Year
2020
Type
review
Volume
52
Issue
6
Pages
910-941
Citations
1755
Access
Closed

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Cite This

Nicolas Vabret, Graham J. Britton, Conor Gruber et al. (2020). Immunology of COVID-19: Current State of the Science. Immunity , 52 (6) , 910-941. https://doi.org/10.1016/j.immuni.2020.05.002

Identifiers

DOI
10.1016/j.immuni.2020.05.002
PMID
32505227
PMCID
PMC7200337

Data Quality

Data completeness: 90%