Abstract
Twenty years ago the concept that immunological mechanisms might regulate carcinogenesis was highly controversial. Today this concept survives in modified form and continues to evolve as our knowledge of the immune system, the etiology of cancer, and tumor antigens expands. This review illustrates how our ideas about immune surveillance have changed in recent years and considers the significance of these changes for the future directions of cancer immunobiology.
Keywords
CarcinogenesisImmune systemCancerAntigenBiologyImmunologyGenetics
MeSH Terms
AnimalsHumansImmunityCellularImmunologic SurveillanceImmunosuppression TherapyNeoplasms
Affiliated Institutions
Related Publications
Immunology of Gynecologic Neoplasms: Analysis of the Prognostic Significance of the Immune Status
Gynecologic Oncology has changed in the last few decades. An increasing proportion of patients is benefiting from long term survival although patients diagnosed with advanced di...
Intraepithelial CD8<sup>+</sup>tumor-infiltrating lymphocytes and a high CD8<sup>+</sup>/regulatory T cell ratio are associated with favorable prognosis in ovarian cancer
In a recent report, [Zhang et al. (2003) N. Engl. J. Med. 348, 203–213], the presence of CD3 + tumor-infiltrating lymphocytes (TILs) was found to correlate with improved surviva...
The interaction between HMGB1 and TLR4 dictates the outcome of anticancer chemotherapy and radiotherapy
Summary: For the last four decades, the treatment of cancer has relied on four treatment modalities, namely surgery, radiotherapy, cytotoxic chemotherapy, and hormonotherapy. Mo...
Prospective identification of tumorigenic breast cancer cells
Breast cancer is the most common malignancy in United States women, accounting for >40,000 deaths each year. These breast tumors are comprised of phenotypically diverse popul...
Immune Therapy for Cancer
Over the past decade, immune therapy has become a standard treatment for a variety of cancers. Monoclonal antibodies, immune adjuvants, and vaccines against oncogenic viruses ar...
Publication Info
- Year
- 1988
- Type
- review
- Volume
- 80
- Issue
- 10
- Pages
- 722-727
- Citations
- 53
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
53
OpenAlex
0
Influential
41
CrossRef
Cite This
M L Kripke
(1988).
Immunoregulation of Carcinogenesis: Past, Present, and Future1.
JNCI Journal of the National Cancer Institute
, 80
(10)
, 722-727.
https://doi.org/10.1093/jnci/80.10.722
Identifiers
- DOI
- 10.1093/jnci/80.10.722
- PMID
- 3290496