Abstract
The functional magnetic resonance imagery responses of declarative memory tasks in the medial temporal lobe (MTL) are examined by using large deformation diffeomorphic metric mapping (LDDMM) to remove anatomical variations across subjects. LDDMM is used to map the structures of the MTL in multiple subjects into extrinsic atlas coordinates; these same diffeomorphic mappings are used to transfer the corresponding functional data activation to the same extrinsic coordinates. The statistical power in the averaged LDDMM mapped signals is significantly increased over conventional Talairach–Tournoux averaging. Activation patterns are highly localized within the MTL. Whereas the present demonstration has been aimed at enhancing alignment within the MTL, this technique is general and can be applied throughout the brain.
Keywords
DiffeomorphismTemporal lobeAtlas (anatomy)Metric (unit)Artificial intelligenceBrain mappingComputer scienceFunctional magnetic resonance imagingPattern recognition (psychology)NeuroscienceComputer visionAnatomyMathematicsPsychologyBiologyPure mathematicsEpilepsy
MeSH Terms
Brain MappingHumansMagnetic Resonance ImagingMemoryTemporal Lobe
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Publication Info
- Year
- 2005
- Type
- article
- Volume
- 102
- Issue
- 27
- Pages
- 9685-9690
- Citations
- 175
- Access
- Closed
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Cite This
Michael I. Miller,
Mirza Faisal Beg,
Can Ceritoglu
et al.
(2005).
Increasing the power of functional maps of the medial temporal lobe by using large deformation diffeomorphic metric mapping.
Proceedings of the National Academy of Sciences
, 102
(27)
, 9685-9690.
https://doi.org/10.1073/pnas.0503892102
Identifiers
- DOI
- 10.1073/pnas.0503892102
- PMID
- 15980148
- PMCID
- PMC1172268