Initial Invasive or Conservative Strategy for Stable Coronary Disease

Abstract

Among patients with stable coronary disease and moderate or severe ischemia, we did not find evidence that an initial invasive strategy, as compared with an initial conservative strategy, reduced the risk of ischemic cardiovascular events or death from any cause over a median of 3.2 years. The trial findings were sensitive to the definition of myocardial infarction that was used. (Funded by the National Heart, Lung, and Blood Institute and others; ISCHEMIA ClinicalTrials.gov number, NCT01471522.).

Keywords

Affiliated Institutions

• Université Paris Cité FR
• Harvard University US
• Assistance Publique – Hôpitaux de Paris FR
• St. Francis Hospital US
• VA New England Healthcare System US
• University of Toronto CA
• Orthopädische Praxis DE
• Flinders University AU
• Icahn School of Medicine at Mount Sinai US
• Cedars-Sinai Medical Center US
• Royal Brompton Hospital GB
• Massachusetts General Hospital US
• Instituto do Coração PT
• New York Hospital Queens US
• Flinders Medical Centre AU
• Northwick Park Hospital GB
• Cardiovascular Research Foundation US
• East Carolina University US
• Columbia University US
• Imperial College London GB
• Associazione Nazionale Medici Cardiologi Ospedalieri IT
• Uppsala University SE
• Semmelweis University HU
• Cornell University US
• Mayo Clinic in Arizona US
• Brigham and Women's Hospital US
• St. Michael's Hospital CA
• Montreal Heart Institute CA
• Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo BR
• Emory University US
• Instituto de Investigación Biomédica de A Coruña ES
• Presbyterian Hospital US
• University of British Columbia CA
• Boston University US
• UCLouvain Saint-Louis Brussels BE
• Saint Luke's Hospital US
• Keio University JP
• All India Institute of Medical Sciences IN
• National Institutes of Health US
• University of Missouri–Kansas City US
• Centro de Investigación Biomédica en Red ES
• NewYork–Presbyterian Hospital US
• Clinical Research Institute US
• Inserm FR
• Hospital Universitario La Paz ES
• Stanford University US
• Albany Medical Center Hospital US
• Atlanta VA Medical Center US
• Vanderbilt University US
• New York University US
• Canadian Heart Research Centre CA

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