Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy

Xingshu Li; Nahyun Kwon; Tian Guo; Zhuang Liu; Juyoung Yoon

doi:10.1002/anie.201805138

Abstract

Abstract Despite its clinical promise, photodynamic therapy (PDT) suffers from a key drawback associated with its oxygen‐dependent nature, which limits its effective use against hypoxic tumors. Moreover, both PDT‐mediated oxygen consumption and microvascular damage further increase tumor hypoxia and, thus, impede therapeutic outcomes. In recent years, numerous investigations have focused on strategies for overcoming this drawback of PDT. These efforts, which are summarized in this review, have produced many innovative methods to avoid the limits of PDT associated with hypoxia.

Keywords

Photodynamic therapyHypoxia (environmental)Tumor hypoxiaMedicineCancer researchIntensive care medicineOxygenChemistryInternal medicineRadiation therapy

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Publication Info

Year: 2018
Type: review
Volume: 57
Issue: 36
Pages: 11522-11531
Citations: 1117
Access: Closed

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APA Style

                            
                                
                                    Xingshu Li, 
                                
                                    Nahyun Kwon, 
                                
                                    Tian Guo
                                
                                et al.
                            
                            (2018). 
                            Innovative Strategies for Hypoxic‐Tumor Photodynamic Therapy. 
                            Angewandte Chemie International Edition
                            , 57
                            (36)
                            , 11522-11531.
                            https://doi.org/10.1002/anie.201805138
                        

Identifiers

DOI: 10.1002/anie.201805138