Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels

Peter C. Brooks; Anthony M.P. Montgomery; Mauricio Rosenfeld; Ralph A. Reisfeld; Tianhua Hu; George Klier; David A. Cheresh

doi:10.1016/0092-8674(94)90007-8

Abstract

A single intravascular injection of a cyclic peptide or monoclonal antibody antagonist of integrin alpha v beta 3 disrupts ongoing angiogenesis on the chick chorioallantoic membrane (CAM). This leads to the rapid regression of histologically distinct human tumors transplanted onto the CAM. Induction of angiogenesis by a tumor or cytokine promotes vascular cell entry into the cell cycle and expression of integrin alpha v beta 3. After angiogenesis is initiated, antagonists of this integrin induce apoptosis of the proliferative angiogenic vascular cells, leaving preexisting quiescent blood vessels unaffected. We demonstrate therefore that ligation of integrin alpha v beta 3 is required for the survival and maturation of newly forming blood vessels, an event essential for the proliferation of tumors.

Keywords

BiologyAngiogenesisIntegrinChorioallantoic membraneNeovascularizationCancer researchApoptosisCell biologyBlood vesselMonoclonal antibodyImmunologyReceptorEndocrinologyAntibody

MeSH Terms

AllantoisAnimalsApoptosisBlood VesselsChick EmbryoChorionHumansIntegrinsNeoplasm TransplantationNeoplasmsNeovascularizationPathologicReceptorsCytoadhesinReceptorsVitronectinTumor CellsCultured

Affiliated Institutions

Scripps Research Institute US

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Publication Info

Year: 1994
Type: article
Volume: 79
Issue: 7
Pages: 1157-1164
Citations: 2268
Access: Closed

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APA Style

                            
                                
                                    Peter C. Brooks, 
                                
                                    Anthony M.P. Montgomery, 
                                
                                    Mauricio Rosenfeld
                                
                                et al.
                            
                            (1994). 
                            Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. 
                            Cell
                            , 79
                            (7)
                            , 1157-1164.
                            https://doi.org/10.1016/0092-8674(94)90007-8
                        

Identifiers

DOI: 10.1016/0092-8674(94)90007-8
PMID: 7528107

Data Quality

Data completeness: 81%