Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury

Yen‐Hsuan Ni , Roland M.H. Schein , Mark W. Smith , Yen‐Hsuan Ni , Roland M.H. Schein , Mark W. Smith , Kathleen M. Swanson , Bruce Thompson , Anitha Vijayan , Suzanne Watnick , Robert A. Star , Peter Peduzzi , Eric W. Young , R. Fissel , W. Fissel , Uptal D. Patel , K. Bélanger , A. E. G. Raine , Nicola Ricci , Matthias Löhr , Puneet Arora , D. Cloen , D. Wassel , L. Yohe , Jamshid Amanzadeh , Jeffrey G. Penfield , Salman Hussain , Ratnaja Katneni , Atul Sajgure , Alan C. Swann , Gena Dolson , V. Ramanathan , G. Tasby , Robert L. Bacallao , Mustafa K. Jaradat , Kencee Graves , Qi Li , Michelle W. Krause , Mary Jo Shaver , Muhammad Alam , Kevin Morris , Tracy A Bland , Elizabeth K. Satter , Jeffrey A. Kraut , Arnold J. Felsenfeld , Barton S. Levine , Glenn T. Nagami , Behran Vaghaiwalla , Joanna Duffney , Jack Moore , Cesar Cely , Edgar A. Jaimes , Daniel H. Kett , Andrew A. Quartin , M. A. Arcia , Allison Barchi-Chung , Vecihi Batuman , Ahmet Taha Alper , Albert W. Dreisbach , E. E. Simon , C. Kulivan , Nabeel Aslam , Ramkumar Mohan , E. Grum , Paul A. Rogers , Steven D. Weisbord , C. Geffel , Ihab Wahba , Deborah Kelly , Jacqueline Walczyk , G. M. Feldman , András Mogyorósi , G. W. Viol , Mark Halverson , Stefan Schmid , H.P. Totten , Francis B. Gabbai , Scott Mullaney , Richard Smith , J. Dingsdale , Stephen Woods , Kirsten L. Johansen , D. Lovett , Ann M. O’Hare , James T. McCarthy , Carlos S. Rosado-Rodriguez , A. Galera , Gloria Rodríguez-Vega , W. Rodriguez , Carmen Mongrut Vilchez , Belinda Young , D.L. Andress , A Lindner , Grace Galvin , N. Gourley , Paul M. Palevsky , Jane Hongyuan Zhang , Theresa O’Connor , Glenn M. Chertow , Susan T. Crowley , Devasmita Choudhury , Kevin W. Finkel , John A. Kellum
2008 New England Journal of Medicine 1,715 citations

Abstract

Intensive renal support in critically ill patients with acute kidney injury did not decrease mortality, improve recovery of kidney function, or reduce the rate of nonrenal organ failure as compared with less-intensive therapy involving a defined dose of intermittent hemodialysis three times per week and continuous renal-replacement therapy at 20 ml per kilogram per hour. (ClinicalTrials.gov number, NCT00076219.)

Keywords

MedicineRenal replacement therapyAcute kidney injuryDialysisHemodialysisSepsisIntensive careOdds ratioRenal functionSurgeryIntensive care medicineInternal medicine

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Publication Info

Year
2008
Type
article
Volume
359
Issue
1
Pages
7-20
Citations
1715
Access
Closed

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Yen‐Hsuan Ni, Roland M.H. Schein, Mark W. Smith et al. (2008). Intensity of Renal Support in Critically Ill Patients with Acute Kidney Injury. New England Journal of Medicine , 359 (1) , 7-20. https://doi.org/10.1056/nejmoa0802639

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DOI
10.1056/nejmoa0802639