Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes

Abstract

A strategy of intensive glucose control, involving gliclazide (modified release) and other drugs as required, that lowered the glycated hemoglobin value to 6.5% yielded a 10% relative reduction in the combined outcome of major macrovascular and microvascular events, primarily as a consequence of a 21% relative reduction in nephropathy. (ClinicalTrials.gov number, NCT00145925.)

Keywords

MedicineHazard ratioGlycated hemoglobinInternal medicineType 2 diabetesRetinopathyNephropathyDiabetes mellitusDiabetic retinopathyAlbuminuriaIncidence (geometry)Stroke (engine)Confidence intervalEndocrinologyRenal function

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Publication Info

Year: 2008
Type: article
Volume: 358
Issue: 24
Pages: 2560-2572
Citations: 7291
Access: Closed

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APA Style

                            
                                
                                    Anushka Patel, 
                                
                                    Stephen MacMahon, 
                                
                                    John Chalmers
                                
                                et al.
                            
                            (2008). 
                            Intensive Blood Glucose Control and Vascular Outcomes in Patients with Type 2 Diabetes. 
                            New England Journal of Medicine
                            , 358
                            (24)
                            , 2560-2572.
                            https://doi.org/10.1056/nejmoa0802987
                        

Identifiers

DOI: 10.1056/nejmoa0802987