Intensive Insulin Therapy in Critically Ill Patients

Abstract

Intensive insulin therapy to maintain blood glucose at or below 110 mg per deciliter reduces morbidity and mortality among critically ill patients in the surgical intensive care unit.

Keywords

MedicineCritically illInsulinInsulin resistanceIntensive care medicineDiabetes mellitusCritical illnessInternal medicineEndocrinology

Affiliated Institutions

KU Leuven BE

Related Publications

Insulin Sensitivity and Insulin Binding to Monocytes in Maturity-Onset Diabetes

Ralph A. DeFronzo , David Deibert , Rosa Hendler +2 more

Tissue sensitive to insulin and insulin binding to monocytes were evaluated in 15 nonobese maturity-onset diabetics and in 16 healthy controls. Insulin sensitivity was determine...

1979 Journal of Clinical Investigation 188 citations

Clinical course and outcomes of critically ill patients with SARS-CoV-2 pneumonia in Wuhan, China: a single-centered, retrospective, observational study

Xiaobo Yang , Yu Yuan , Jiqian Xu +13 more

An ongoing outbreak of pneumonia associated with the severe acute respiratory coronavirus 2 (SARS-CoV-2) started in December, 2019, in Wuhan, China. Information about critically...

2020 The Lancet Respiratory Medicine 10565 citations

Glycometabolic State at Admission: Important Risk Marker of Mortality in Conventionally Treated Patients With Diabetes Mellitus and Acute Myocardial Infarction

Klas Malmberg , Anna Norhammar , Hans Wedel +1 more

Background —The Diabetes and Insulin-Glucose Infusion in Acute Myocardial Infarction (DIGAMI) study addressed prognostic factors and the effects of concomitant treatment and gly...

1999 Circulation 851 citations

Surviving Sepsis Campaign

R. Phillip Dellinger , Mitchell M. Levy , Andrew Rhodes +20 more

To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. A consensus committee of 68 internat...

2013 Critical Care Medicine 9630 citations

Implementation of an evidence-based “standard operating procedure” and outcome in septic shock*

Andreas Kortgen , Petra Niederprüm , Michael Bauer

The combined approach of early goal-directed therapy, intensive insulin therapy, hydrocortisone administration, and additional application of rhAPC in selected cases seems to fa...

2006 Critical Care Medicine 316 citations

Publication Info

Year: 2001
Type: article
Volume: 345
Issue: 19
Pages: 1359-1367
Citations: 9922
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Intensive Insulin Therapy in Critically Ill Patients

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

9922

OpenAlex

Cite This

APA Style

                            
                                
                                    Greet Van den Berghe, 
                                
                                    Pieter Wouters, 
                                
                                    Frank Weekers
                                
                                et al.
                            
                            (2001). 
                            Intensive Insulin Therapy in Critically Ill Patients. 
                            New England Journal of Medicine
                            , 345
                            (19)
                            , 1359-1367.
                            https://doi.org/10.1056/nejmoa011300
                        

Identifiers

DOI: 10.1056/nejmoa011300