Abstract

Microbiologically it was demonstrated that amino acids, e.g. cysteine (CySH), and other compounds, e.g. sodium thioglycollate, containing thiol groups neutralized the activity of silver nitrate against Pseudomonas aeruginosa PAO1. Amino acids with disulphide bonds were inactive, with the exception of L-cystine dimethyl ester, as were all amino acids with no sulphur groups. Iodoacetamide reacted with CySH to produce a CyS-acetamide complex that was unable to quench the activity of Ag+. Chemical analyses using cyclic voltammetry demonstrated that high coordination numbers (3.1) were obtained with thiol-containing amino acids and low numbers (0.28-0.4) with other amino acids. Both microbiologically and chemically, the results imply that interaction of Ag+ with thiol groups plays an essential role in bacterial inactivation.

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WelshPharmacyHistoryLibrary scienceIrishMedicineFamily medicineArchaeologyComputer sciencePhilosophy

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Publication Info

Year
1997
Type
article
Volume
25
Issue
4
Pages
279-283
Citations
834
Access
Closed

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Shiuan-Fei Liau, Dan Read, W. Pugh et al. (1997). Interaction of silver nitrate with readily identifiable groups: relationship to the antibacterialaction of silver ions. Letters in Applied Microbiology , 25 (4) , 279-283. https://doi.org/10.1046/j.1472-765x.1997.00219.x

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DOI
10.1046/j.1472-765x.1997.00219.x