Abstract
Acidic matrix macromolecules are intimately involved in biological crystal growth. In vitro experiments, in which crystals of calcium dicarboxylate salts were grown in the presence of aspartic acid-rich proteins, revealed a stereochemical property common to all the interacting faces. Calcite crystals are nucleated on stereochemically analogous faces when proteins are adsorbed onto a rigid substrate. The importance of this property in biomineralization is discussed.
Keywords
BiomineralizationMacromoleculeAspartic acidChemistryCalciteProtein crystallizationCrystal (programming language)CrystallographySubstrate (aquarium)BiochemistryAmino acidChemical engineeringCrystallizationBiologyOrganic chemistryMineralogy
MeSH Terms
AnimalsAspartic AcidBone MatrixCalcificationPhysiologicCalciumCrystallizationDicarboxylic AcidsExtracellular MatrixIsoelectric PointModelsBiologicalMolluscaOsteogenesis
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Publication Info
- Year
- 1985
- Type
- article
- Volume
- 82
- Issue
- 12
- Pages
- 4110-4114
- Citations
- 1066
- Access
- Closed
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Cite This
Lia Addadi,
Stephen Weiner
(1985).
Interactions between acidic proteins and crystals: stereochemical requirements in biomineralization..
Proceedings of the National Academy of Sciences
, 82
(12)
, 4110-4114.
https://doi.org/10.1073/pnas.82.12.4110
Identifiers
- DOI
- 10.1073/pnas.82.12.4110
- PMID
- 3858868
- PMCID
- PMC397944