Abstract
Recent studies suggest that some T and B lymphocyte cell lines bind to the integrin lymphocyte function-associated molecule 1 (LFA-1) chiefly through a pathway independent of its two known counter-receptors, intercellular adhesion molecules (ICAMs)-1 and -2. A monoclonal antibody (mAb) was raised that, in combination with blocking mAb to ICAM-1 and ICAM-2, can completely inhibit binding of these cell lines to purified LFA-1. This third ligand, designated ICAM-3 based on its functional relatedness to ICAM-1 and -2, is a highly glycosylated protein of 124,000 Mr. It is well expressed on all leukocytes and absent from endothelial cells. In assays of adhesion of resting lymphocytes to purified LFA-1, ICAM-3 is by far the most functionally important ICAM, implying an important role for ICAM-3 in the generation of immune responses.
Keywords
Lymphocyte function-associated antigen 1Cell adhesion moleculeIntercellular Adhesion Molecule-1Intercellular adhesion moleculeCell biologyBiologyCell adhesionLymphocyteICAM-1Monoclonal antibodyReceptorIntegrinAdhesionIntracellularCell–cell interactionLymphocyte homing receptorImmune systemMolecular biologyAntibodyChemistryImmunologyCellBiochemistry
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Publication Info
- Year
- 1992
- Type
- article
- Volume
- 175
- Issue
- 1
- Pages
- 185-190
- Citations
- 432
- Access
- Closed
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Cite This
Antonin R. de Fougerolles,
Timothy A. Springer
(1992).
Intercellular adhesion molecule 3, a third adhesion counter-receptor for lymphocyte function-associated molecule 1 on resting lymphocytes..
The Journal of Experimental Medicine
, 175
(1)
, 185-190.
https://doi.org/10.1084/jem.175.1.185
Identifiers
- DOI
- 10.1084/jem.175.1.185