Abstract

Interleukin (IL)-17 is a pro-inflammatory cytokine that is produced by activated T cells. Despite increasing evidence that high levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis, and multiple sclerosis, the regulation of its expression is not well characterized. We observe that IL-17 production is increased in response to the recently described cytokine IL-23. We present evidence that murine IL-23, which is produced by activated dendritic cells, acts on memory T cells, resulting in elevated IL-17 secretion. IL-23 also induced expression of the related cytokine IL-17F. IL-23 is a heterodimeric cytokine and shares a subunit, p40, with IL-12. In contrast to IL-23, IL-12 had only marginal effects on IL-17 production. These data suggest that during a secondary immune response, IL-23 can promote an activation state with features distinct from the well characterized Th1 and Th2 profiles.

Keywords

CytokineImmunologyInterleukin 17Interleukin 23Interleukin 10Immune systemBiologyInterleukin 4InterleukinInterleukin 5Cell biology

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Year
2003
Type
article
Volume
278
Issue
3
Pages
1910-1914
Citations
1820
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Closed

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Sudeepta Aggarwal, Nico Ghilardi, Ming-Hong Xie et al. (2003). Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17. Journal of Biological Chemistry , 278 (3) , 1910-1914. https://doi.org/10.1074/jbc.m207577200

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DOI
10.1074/jbc.m207577200