Abstract
Human interleukin-10 (IL-10) is a potent anti-inflammatory cytokine that inhibits the synthesis of the major proinflammatory cytokines and chemokines. IL-10 is the principal TH2-type cytokine that upregulates humoral immune responses and attenuates cell-mediated immune reactions. This cytokine has a number of immunomodulatory properties that might be clinically useful in a variety of inflammatory and infectious disease states. Clinical trials with human recombinant IL-10 are already in progress. Carefully selected patients with inflammatory conditions may benefit from IL-10 therapy if concomitant infectious diseases are recognized and treated appropriately.
Keywords
MedicineImmunologyProinflammatory cytokineCytokineChemokineImmune systemInfectious disease (medical specialty)DiseaseInterleukinClinical trialInflammationInternal medicine
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Publication Info
- Year
- 1998
- Type
- review
- Volume
- 27
- Issue
- 6
- Pages
- 1497-1507
- Citations
- 115
- Access
- Closed
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Cite This
Steven M. Opal,
Janice C. Wherry,
Paul Grint
(1998).
Interleukin‐10: Potential Benefits and Possible Risks in Clinical Infectious Diseases.
Clinical Infectious Diseases
, 27
(6)
, 1497-1507.
https://doi.org/10.1086/515032
Identifiers
- DOI
- 10.1086/515032