Abstract

Mammals adapt to a rapidly changing world because of the sophisticated cognitive functions that are supported by the neocortex. The neocortex, which forms almost 80% of the human brain, seems to have arisen from repeated duplication of a stereotypical microcircuit template with subtle specializations for different brain regions and species. The quest to unravel the blueprint of this template started more than a century ago and has revealed an immensely intricate design. The largest obstacle is the daunting variety of inhibitory interneurons that are found in the circuit. This review focuses on the organizing principles that govern the diversity of inhibitory interneurons and their circuits.

Keywords

NeocortexInhibitory postsynaptic potentialNeuroscienceBiology

MeSH Terms

AnimalsAxonsCalcium-Binding ProteinsDendritesElectrophysiologyHumansInterneuronsIon ChannelsMembrane PotentialsNeocortexNerve NetNeural InhibitionNeuronsNeuropeptidesSynapsesSynaptic Transmission

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Publication Info

Year
2004
Type
review
Volume
5
Issue
10
Pages
793-807
Citations
2970
Access
Closed

External Links

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Cite This

Henry Markram, Maria Toledo‐Rodriguez, Yun Wang et al. (2004). Interneurons of the neocortical inhibitory system. Nature reviews. Neuroscience , 5 (10) , 793-807. https://doi.org/10.1038/nrn1519

Identifiers

DOI
10.1038/nrn1519
PMID
15378039

Data Quality

Data completeness: 81%