Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy

2019 Immunity 1,470 citations

Keywords

BlockadeCancer researchImmune checkpointBiologyImmunotherapyCD8Cytotoxic T cellMelanomaStem cellImmunologyImmune systemCell biologyReceptor

MeSH Terms

AnimalsAntibodiesMonoclonalCD8-Positive T-LymphocytesCell DifferentiationCell ProliferationHepatitis A Virus Cellular Receptor 2Hepatocyte Nuclear Factor 1-alphaHumansImmunotherapyLymphocytesTumor-InfiltratingMelanomaMelanomaExperimentalMiceMiceInbred C57BLProgrammed Cell Death 1 ReceptorStem CellsT-Lymphocyte Subsets

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Publication Info

Year
2019
Type
article
Volume
50
Issue
1
Pages
195-211.e10
Citations
1470
Access
Closed

Citation Metrics

1470
OpenAlex
41
Influential
1344
CrossRef

Cite This

Imran Siddiqui, Karin Schaeuble, Vijaykumar Chennupati et al. (2019). Intratumoral Tcf1+PD-1+CD8+ T Cells with Stem-like Properties Promote Tumor Control in Response to Vaccination and Checkpoint Blockade Immunotherapy. Immunity , 50 (1) , 195-211.e10. https://doi.org/10.1016/j.immuni.2018.12.021

Identifiers

DOI
10.1016/j.immuni.2018.12.021
PMID
30635237

Data Quality

Data completeness: 77%