Abstract

Enhanced vascular permeability in tumor tissue has profound pathological consequences in tumor biology. However, details of the mechanism involved are not clear. The present work on tumor vascular permeability has led to the following three findings, (i) Ascitic tumor fluid contained kinin (about 1‐40 ng/ml), which is known to enhance vascular permeability and induce pain in vivo , (ii) Kinin is generated via the kallikrein‐dependent cascade in the ascitic tumor fluid. By blocking this kinin‐generating cascade with Kunitz‐type soybean trypsin inhibitor the formation of ascites was suppressed, (iii) Blocking of kinin‐degrading enzymes (kininases I and II) by an appropriate kininase inhibitor (e.g., captopril) may result in increased permeability, leading to accumulation of the ascitic fluid. This phenomenon was verified by an about 1.2‐1.5 fold increase in leakage of 51 Cr‐labeled bovine serum albumin into the ascites when kininase inhibitors had been administered orally 30 min before intravenous administration of the bovine serum albumin.

Keywords

KininBradykininVascular permeabilityIn vivoBovine serum albuminExtravasationChemistryAlbuminAscitesCaptoprilSerum albuminEndocrinologyPharmacologyInternal medicineMedicinePathologyBiologyBiochemistryReceptor

MeSH Terms

AnimalsAscitesBradykininCapillary PermeabilityCaptoprilKininsLysine CarboxypeptidaseNeoplasmsExperimentalRatsSerum AlbuminBovineTrypsin Inhibitors

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Publication Info

Year
1988
Type
article
Volume
79
Issue
12
Pages
1327-1334
Citations
159
Access
Closed

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Cite This

Yasuhiro Matsumura, Masami Kimura, Tetsuro Yamamoto et al. (1988). Involvement of the Kinin‐generating Cascade in Enhanced Vascular Permeability in Tumor Tissue. Japanese Journal of Cancer Research , 79 (12) , 1327-1334. https://doi.org/10.1111/j.1349-7006.1988.tb01563.x

Identifiers

DOI
10.1111/j.1349-7006.1988.tb01563.x
PMID
3148603
PMCID
PMC5917657

Data Quality

Data completeness: 86%