Abstract

Structural genomics seeks to expand rapidly the number of protein structures in order to extract the maximum amount of information from genomic sequence databases. The advent of several large-scale projects worldwide leads to many new challenges in the field of crystallographic macromolecular structure determination. A novel software package called PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography) is therefore being developed. This new software will provide the necessary algorithms to proceed from reduced intensity data to a refined molecular model and to facilitate structure solution for both the novice and expert crystallographer.

Keywords

Python (programming language)SoftwareStructural genomicsComputer scienceSoftware engineeringComputational biologyComputational scienceData scienceData miningProtein structureChemistryBiologyProgramming language

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Year
2002
Type
article
Volume
58
Issue
11
Pages
1948-1954
Citations
4339
Access
Closed

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Paul D. Adams, Ralf W. Grosse‐Kunstleve, Li‐Wei Hung et al. (2002). <i>PHENIX</i>: building new software for automated crystallographic structure determination. Acta Crystallographica Section D Biological Crystallography , 58 (11) , 1948-1954. https://doi.org/10.1107/s0907444902016657

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DOI
10.1107/s0907444902016657