<i>Porphyromonas gingivalis</i> in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors

Stephen S. Dominy; Casey Lynch; Florian Ermini; Małgorzata Benedyk; Agata Marczyk; Andrei W. Konradi; Mai Nguyen; Ursula Haditsch; Debasish Raha; Christina Griffin; Leslie J. Holsinger; Shirin Arastu‐Kapur; Samer E. Kaba; Alexander Lee; Mark I. Ryder; Barbara Potempa; Piotr Mydel; Annelie Hellvard; Karina Adamowicz; Hatice Hastürk; Glenn D. Walker; Eric C. Reynolds; Richard L. M. Faull; Maurice A. Curtis; Mike Dragunow; Jan Potempa

doi:10.1126/sciadv.aau3333

Abstract

Gingipains from Porphyromonas gingivalis drive Alzheimer’s pathology and can be blocked with small-molecule inhibitors.

Keywords

Porphyromonas gingivalisDiseaseAlzheimer's diseaseCausationMedicineBiologyNeurosciencePathologyInternal medicinePeriodontitisPhilosophy

MeSH Terms

AgedAlzheimer DiseaseAmyloid beta-PeptidesAnimalsBacteroidaceae InfectionsBrainCell LineTumorDisease ModelsAnimalFemaleGingipain Cysteine EndopeptidasesHumansMaleMiceMiceInbred BALB CMiddle AgedNeuroprotective AgentsPeptide FragmentsPilot ProjectsPorphyromonas gingivalisProspective StudiesSalivaSmall Molecule Librariestau Proteins

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Publication Info

Year: 2019
Type: article
Volume: 5
Issue: 1
Pages: eaau3333-eaau3333
Citations: 1672
Access: Closed

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APA Style

                            
                                
                                    Stephen S. Dominy, 
                                
                                    Casey Lynch, 
                                
                                    Florian Ermini
                                
                                et al.
                            
                            (2019). 
                            <i>Porphyromonas gingivalis</i> in Alzheimer’s disease brains: Evidence for disease causation and treatment with small-molecule inhibitors. 
                            Science Advances
                            , 5
                            (1)
                            , eaau3333-eaau3333.
                            https://doi.org/10.1126/sciadv.aau3333
                        

Identifiers

DOI: 10.1126/sciadv.aau3333
PMID: 30746447
PMCID: PMC6357742

Data Quality

Data completeness: 90%