IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling

Abstract

The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-κB) activation in mammals and is similar to the Toll pathway in Drosophila : the IL-1R–associated kinase (IRAK) is homologous to Pelle. Two additional proximal mediators were identified that are required for IL-1R–induced NF-κB activation: IRAK-2, a Pelle family member, and MyD88, a death domain–containing adapter molecule. Both associate with the IL-1R signaling complex. Dominant negative forms of either attenuate IL-1R–mediated NF-κB activation. Therefore, IRAK-2 and MyD88 may provide additional therapeutic targets for inhibiting IL-1–induced inflammation.

Keywords

Signal transductionCell biologyKinaseReceptorBiologyChemistryGenetics

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Publication Info

Year: 1997
Type: article
Volume: 278
Issue: 5343
Pages: 1612-1615
Citations: 1155
Access: Closed

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APA Style

                            
                                
                                    Marta Muzio, 
                                
                                    Jian Ni, 
                                
                                    Ping Feng
                                
                                et al.
                            
                            (1997). 
                            IRAK (Pelle) Family Member IRAK-2 and MyD88 as Proximal Mediators of IL-1 Signaling. 
                            Science
                            , 278
                            (5343)
                            , 1612-1615.
                            https://doi.org/10.1126/science.278.5343.1612
                        

Identifiers

DOI: 10.1126/science.278.5343.1612