<i>SF3B1</i> and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia

Lili Wang; Michael S. Lawrence; Youzhong Wan; Petar Stojanov; Carrie Sougnez; Kristen Stevenson; Lillian Werner; Andrey Sivachenko; David S. DeLuca; Li Zhang; Wandi Zhang; Alexander R. Vartanov; Stacey M. Fernandes; Natalie R. Goldstein; Eric G. Folco; Kristian Cibulskis; Bethany Tesar; Quinlan Sievers; Erica Shefler; Stacey Gabriel; Nir Hacohen; Robin Reed; Matthew Meyerson; Todd R. Golub; Eric S. Lander; Donna Neuberg; Jennifer R. Brown; Gad Getz; Catherine J. Wu

doi:10.1056/nejmoa1109016

Abstract

Our study defines the landscape of somatic mutations in chronic lymphocytic leukemia and highlights pre-mRNA splicing as a critical cellular process contributing to chronic lymphocytic leukemia.

Keywords

Chronic lymphocytic leukemiaLeukemiaSpliceosomeGermlineSomatic cellGermline mutationCancer researchRNA splicingMutationCancerGeneBiologyExome sequencingGeneticsMedicineRNA

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Publication Info

Year: 2011
Type: article
Volume: 365
Issue: 26
Pages: 2497-2506
Citations: 1052
Access: Closed

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APA Style

                            
                                
                                    Lili Wang, 
                                
                                    Michael S. Lawrence, 
                                
                                    Youzhong Wan
                                
                                et al.
                            
                            (2011). 
                            <i>SF3B1</i> and Other Novel Cancer Genes in Chronic Lymphocytic Leukemia. 
                            New England Journal of Medicine
                            , 365
                            (26)
                            , 2497-2506.
                            https://doi.org/10.1056/nejmoa1109016
                        

Identifiers

DOI: 10.1056/nejmoa1109016