Abstract

Leishmaniasis is a poverty-related disease with two main clinical forms: visceral leishmaniasis and cutaneous leishmaniasis. An estimated 0·7-1 million new cases of leishmaniasis per year are reported from nearly 100 endemic countries. The number of reported visceral leishmaniasis cases has decreased substantially in the past decade as a result of better access to diagnosis and treatment and more intense vector control within an elimination initiative in Asia, although natural cycles in transmission intensity might play a role. In east Africa however, the case numbers of this fatal disease continue to be sustained. Increased conflict in endemic areas of cutaneous leishmaniasis and forced displacement has resulted in a surge in these endemic areas as well as clinics across the world. WHO lists leishmaniasis as one of the neglected tropical diseases for which the development of new treatments is a priority. Major evidence gaps remain, and new tools are needed before leishmaniasis can be definitively controlled.

Keywords

LeishmaniasisMedicineImmunology

MeSH Terms

AnimalsAntiprotozoal AgentsCoinfectionDisease VectorsGlobal HealthHIV InfectionsHumansLeishmaniaLeishmaniasisCutaneousLeishmaniasisVisceral

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Publication Info

Year
2018
Type
review
Volume
392
Issue
10151
Pages
951-970
Citations
1775
Access
Closed

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Cite This

Sakib Burza, Simon L. Croft, Marleen Boelaert (2018). Leishmaniasis. The Lancet , 392 (10151) , 951-970. https://doi.org/10.1016/s0140-6736(18)31204-2

Identifiers

DOI
10.1016/s0140-6736(18)31204-2
PMID
30126638

Data Quality

Data completeness: 86%