Keywords
Cancer researchCytotoxic T cellTargeted therapyLigand (biochemistry)Radiation therapyAntigenMalignant cellsChemotherapyMedicineCancerCancer cellImmunologyChemistryReceptorInternal medicineIn vitroBiochemistry
Affiliated Institutions
Related Publications
Mapping Tumor Epitope Space by Direct Selection of Single-Chain Fv Antibody Libraries on Prostate Cancer Cells
Abstract The identification of tumor-specific cell surface antigens is a critical step toward the development of targeted therapeutics for cancer. The epitope space at the tumor...
Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes.
T cell costimulation by molecules on the antigen presenting cell (APC) is required for optimal T cell proliferation. The B7 molecule on APC binds the T lymphocyte receptor CD28,...
The extracellular region of ErbB4 adopts a tethered conformation in the absence of ligand
The human ErbB family of receptor tyrosine kinases comprises the epidermal growth factor receptor (EGFR/ErbB1/HER1), ErbB2 (HER2/Neu), ErbB3 (HER3), and ErbB4 (HER4). ErbBs play...
Binding specificities and affinities of <i>egf</i> domains for ErbB receptors
ErbB receptor activation is a complex process and is dependent upon the type and number of receptors expressed on a given cell. Previous studies with defined combinations of Erb...
The ErbB-2/HER2 oncoprotein of human carcinomas may function solely as a shared coreceptor for multiple stroma-derived growth factors
The erbB-2 / HER2 oncogene is overexpressed in a significant fraction of human carcinomas of the breast, ovary, and lung in a manner that correlates with poor prognosis. Althoug...
Publication Info
- Year
- 2002
- Type
- review
- Volume
- 2
- Issue
- 10
- Pages
- 750-763
- Citations
- 1617
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1617
OpenAlex
Cite This
Theresa M. Allen
(2002).
Ligand-targeted therapeutics in anticancer therapy.
Nature reviews. Cancer
, 2
(10)
, 750-763.
https://doi.org/10.1038/nrc903
Identifiers
- DOI
- 10.1038/nrc903