Long non-coding RNA HOTAIR: A novel oncogene (Review)

Abstract

Long non-coding RNAs (lncRNAs) have been found to be pervasively transcribed in the genome and are critical regulators of the epigenome. Increasing evidence suggests that lncRNAs are aberrantly expressed in several types of human cancer and that they are important in the initiation, development and metastasis of human cancer. Previous studies have revealed that HOX transcript antisense intergenic RNA (HOTAIR) was frequently upregulated in various types of cancer, including breast cancer, esophageal cancer, lung cancer and gastric cancer. In addition, patients with high expression levels of HOTAIR have a significantly poorer prognosis, compared with those with low levels of expression. HOTAIR is involved in the control of cell apoptosis, growth, metastasis, angiogenesis, DNA repair and tumor cells metabolism. The present review provides an overview of the current knowledge concerning the role of HOTAIR in tumor development and progression.

Keywords

HOTAIROncogeneBiologyCancer researchCancerLong non-coding RNAMetastasisEpigenomeHox geneCell cycleAngiogenesisRNADNA methylationGeneticsGene expressionGene

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Publication Info

Year: 2015
Type: review
Volume: 12
Issue: 4
Pages: 5611-5618
Citations: 131
Access: Closed

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APA Style

                            
                                    Xin Yu, 
                                
                                    Zheng Li
                                
                            (2015). 
                            Long non-coding RNA HOTAIR: A novel oncogene (Review). 
                            Molecular Medicine Reports
                            , 12
                            (4)
                            , 5611-5618.
                            https://doi.org/10.3892/mmr.2015.4161

Identifiers

DOI: 10.3892/mmr.2015.4161