Abstract

Macrophages can be affected by a variety of factors to change their phenotype and thus affect their function. Activated macrophages are usually divided into two categories, M1-like macrophages and M2-like macrophages. Both M1 macrophages and M2 macrophages are closely related to inflammatory responses, among which M1 macrophages are mainly involved in pro-inflammatory responses and M2 macrophages are mainly involved in anti-inflammatory responses. Improving the inflammatory environment by modulating the activation state of macrophages is an effective method for the treatment of diseases. In this review, we analyzed the mechanism of macrophage polarization from the tumor microenvironment, nanocarriers, nuclear receptor PPARγ, phagocytosis, NF-κB signaling pathways, and other pathways.

Keywords

Macrophage polarizationMacrophagePhagocytosisCell biologyInflammationNanocarriersMacrophage-activating factorSignal transductionChemistryFunction (biology)ImmunologyCancer researchBiologyIn vitroBiochemistryPharmacologyDrug

MeSH Terms

AnimalsHumansMacrophagesSignal Transduction

Affiliated Institutions

Related Publications

Publication Info

Year
2020
Type
review
Volume
877
Pages
173090-173090
Citations
2126
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

2126
OpenAlex
54
Influential
1911
CrossRef

Cite This

Yunna Chen, Mengru Hu, Lei Wang et al. (2020). Macrophage M1/M2 polarization. European Journal of Pharmacology , 877 , 173090-173090. https://doi.org/10.1016/j.ejphar.2020.173090

Identifiers

DOI
10.1016/j.ejphar.2020.173090
PMID
32234529

Data Quality

Data completeness: 86%