Macrophages and Metabolism in the Tumor Microenvironment

Abstract

Tumor-associated macrophages (TAMs) constitute a plastic and heterogeneous cell population of the tumor microenvironment (TME) that can account for up to 50% of some solid neoplasms. Most often, TAMs support disease progression and resistance to therapy by providing malignant cells with trophic and nutritional support. However, TAMs can mediate antineoplastic effects, especially in response to pharmacological agents that boost their phagocytic and oxidative functions. Thus, TAMs and their impact on the overall metabolic profile of the TME have a major influence on tumor progression and resistance to therapy, de facto constituting promising targets for the development of novel anticancer agents. Here, we discuss the metabolic circuitries whereby TAMs condition the TME to support tumor growth and how such pathways can be therapeutically targeted.

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Affiliated Institutions

• Suzhou Institute of Systems Medicine CN
• University of Rome Tor Vergata IT
• Université Paris Cité FR
• Chinese Academy of Sciences CN
• Assistance Publique – Hôpitaux de Paris FR
• Inserm FR
• Karolinska University Hospital SE
• Délégation Paris 5 FR
• Sorbonne Université FR
• Yale University US
• Italian institute for Genomic Medicine IT
• Institut Gustave Roussy FR
• Istituti di Ricovero e Cura a Carattere Scientifico IT
• Candiolo Cancer Institute IT
• Centre de Recherche des Cordeliers FR
• Cornell University US
• Oregon Health & Science University US
• Hôpital Européen FR
• Hôpital Européen Georges-Pompidou FR

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