Abstract

Abstract We have exploited "progeny testing" to map quantitative trait loci (QTL) underlying the genetic variation of milk production in a selected dairy cattle population. A total of 1,518 sires, with progeny tests based on the milking performances of > 150,000 daughters jointly, was genotyped for 159 autosomal microsatellites bracketing 1645 centimorgan or approximately two thirds of the bovine genome. Using a maximum likelihood multilocus linkage analysis accounting for variance heterogeneity of the phenotypes, we identified five chromosomes giving very strong evidence (LOD score > or = 3) for the presence of a QTL controlling milk production: chromosomes 1, 6, 9, 10 and 20. These findings demonstrate that loci with considerable effects on milk production are still segregating in highly selected populations and pave the way toward marker-assisted selection in dairy cattle breeding.

Keywords

BiologyQuantitative trait locusCentimorganGeneticsMicrosatellitePopulationDairy cattleSelection (genetic algorithm)Linkage disequilibriumTraitAlleleGenotypeSingle-nucleotide polymorphismGene mappingGeneChromosome

Related Publications

Publication Info

Year
1995
Type
article
Volume
139
Issue
2
Pages
907-920
Citations
625
Access
Closed

External Links

View on DOI.org

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

625
OpenAlex

Cite This

A. Mishra, Ronald Okimoto, A. T. Pasquino et al. (1995). Mapping quantitative trait loci controlling milk production in dairy cattle by exploiting progeny testing.. Genetics , 139 (2) , 907-920. https://doi.org/10.1093/genetics/139.2.907

Identifiers

DOI
10.1093/genetics/139.2.907