Abstract
Marrow stromal cells can be isolated from other cells in marrow by their tendency to adhere to tissue culture plastic. The cells have many of the characteristics of stem cells for tissues that can roughly be defined as mesenchymal, because they can be differentiated in culture into osteoblasts, chondrocytes, adipocytes, and even myoblasts. Therefore, marrow stromal cells present an intriguing model for examining the differentiation of stem cells. Also, they have several characteristics that make them potentially useful for cell and gene therapy.
Keywords
Stromal cellStem cellBone marrowMesenchymal stem cellClinical uses of mesenchymal stem cellsStem cell transplantation for articular cartilage repairCell biologyAdult stem cellBiologyLymph node stromal cellAmniotic stem cellsCell cultureCellular differentiationPathologyCancer researchImmunologyMedicineGeneGenetics
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Publication Info
- Year
- 1997
- Type
- review
- Volume
- 276
- Issue
- 5309
- Pages
- 71-74
- Citations
- 4625
- Access
- Closed
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Cite This
Darwin J. Prockop
(1997).
Marrow Stromal Cells as Stem Cells for Nonhematopoietic Tissues.
Science
, 276
(5309)
, 71-74.
https://doi.org/10.1126/science.276.5309.71
Identifiers
- DOI
- 10.1126/science.276.5309.71