Abstract
Adjusted-dose warfarin and antiplatelet agents reduce stroke by approximately 60% and by approximately 20%, respectively, in patients who have atrial fibrillation. Warfarin is substantially more efficacious (by approximately 40%) than antiplatelet therapy. Absolute increases in major extracranial hemorrhage associated with antithrombotic therapy in participants from the trials included in this meta-analysis were less than the absolute reductions in stroke. Judicious use of antithrombotic therapy importantly reduces stroke for most patients who have atrial fibrillation.
Keywords
MedicineAntithromboticAtrial fibrillationWarfarinStroke (engine)Randomized controlled trialInternal medicineMeta-analysisClinical trialCardiology
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Publication Info
- Year
- 2007
- Type
- review
- Volume
- 146
- Issue
- 12
- Pages
- 857-867
- Citations
- 4729
- Access
- Closed
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Cite This
Robert G. Hart,
Lesly A. Pearce,
Maria I. Aguilar
(2007).
Meta-analysis: Antithrombotic Therapy to Prevent Stroke in Patients Who Have Nonvalvular Atrial Fibrillation.
Annals of Internal Medicine
, 146
(12)
, 857-867.
https://doi.org/10.7326/0003-4819-146-12-200706190-00007
Identifiers
- DOI
- 10.7326/0003-4819-146-12-200706190-00007