Keywords
AnabolismCell growthCatabolismBiologyMetabolic pathwayCell biologyCell metabolismMetabolismCancer cellBioenergeticsCellNutrient sensingBiochemistrySignal transductionCancerMitochondrionGenetics
Affiliated Institutions
Related Publications
The PI3K–AKT network at the interface of oncogenic signalling and cancer metabolism
The altered metabolic programme of cancer cells facilitates their cell-autonomous proliferation and survival. In normal cells, signal transduction pathways control core cellular...
Rethinking the Regulation of Cellular Metabolism
Most biologists working today have not considered the problem of how signal transduction events, which commit cells to energetically demanding processes such as growth and divis...
The multifaceted contributions of mitochondria to cellular metabolism
Although classically appreciated for their role as the powerhouse of the cell, the metabolic functions of mitochondria reach far beyond bioenergetics. In this Review, we discuss...
Cancer metabolism: looking forward
Tumour initiation and progression requires the metabolic reprogramming of cancer cells. Cancer cells autonomously alter their flux through various metabolic pathways in order to...
Autophagy in metazoans: cell survival in the land of plenty
Cells require a constant supply of macromolecular precursors and oxidizable substrates to maintain viability. Unicellular eukaryotes lack the ability to regulate nutrient concen...
Publication Info
- Year
- 2019
- Type
- review
- Volume
- 20
- Issue
- 7
- Pages
- 436-450
- Citations
- 1040
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
1040
OpenAlex
Cite This
Jiajun Zhu,
Craig B. Thompson
(2019).
Metabolic regulation of cell growth and proliferation.
Nature Reviews Molecular Cell Biology
, 20
(7)
, 436-450.
https://doi.org/10.1038/s41580-019-0123-5
Identifiers
- DOI
- 10.1038/s41580-019-0123-5