Abstract
Inflammation and hypercoagulability predispose to atherothrombosis and seem to be important features of the metabolic syndrome. The most convincing evidence is the association with increased levels of C-reactive protein. The hemostatic abnormality that has been most consistently associated with insulin resistance is an elevated plasminogen activator inhibitor-1 level. In contrast, markers of hypercoagulability have been associated inconsistently with hyperinsulinemia and glucose intolerance. Fibrinogen clusters with inflammatory factors, which suggests involvement of adipose tissue-generated inflammatory cytokines. Elevated von Willebrand's factor and factor VIII levels aggregate with indicators of endothelial injury,whereas vitamin K-dependent coagulation proteins correlate with triglyceride levels.
Keywords
MedicineInternal medicineInflammationFibrinogenEndocrinologyInsulin resistanceVon Willebrand factorHyperinsulinemiaPlasminogen activatorMetabolic syndromeDiabetes mellitusInsulinPlatelet
MeSH Terms
Blood Coagulation DisordersHumansInflammationMetabolic Syndrome
Affiliated Institutions
Related Publications
Adipose tissue, insulin action and vascular disease: inflammatory signals
Insulin resistance, both in nondiabetic and diabetic subjects, is frequently associated with obesity, particularly an excess of central fat. Many of the features that have been ...
Tissue factor gene expression in the adipose tissues of obese mice
Altered expression of proteins of the fibrinolytic and coagulation cascades in obesity may contribute to the cardiovascular risk associated with this condition. We previously re...
Risk Variable Clustering in the Insulin Resistance Syndrome: The Framingham Offspring Study
Insulin resistance has been hypothesized to unify the clustering of hypertension, glucose intolerance, hyper-insulinemia, increased levels of triglyceride and decreased HDL chol...
The Time for Cardiovascular Inflammation Reduction Trials Has Arrived
I nflammation is a major determinant of atherothrombosis, and based on more than a decade of consistent prospective epidemiological evidence, the inflammatory biomarker highsens...
Hypertriglyceridemic Waist
Background —The present study tested the hypothesis that simple variables, such as waist circumference and fasting plasma triglyceride (TG) concentrations, could be used as scre...
Publication Info
- Year
- 2004
- Type
- review
- Volume
- 33
- Issue
- 2
- Pages
- 431-453
- Citations
- 142
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
142
OpenAlex
2
Influential
100
CrossRef
Cite This
Sridevi Devaraj,
Robert S. Rosenson,
Ishwarlal Jialal
(2004).
Metabolic syndrome: an appraisal of the pro-inflammatory and procoagulant status.
Endocrinology and Metabolism Clinics of North America
, 33
(2)
, 431-453.
https://doi.org/10.1016/j.ecl.2004.03.008
Identifiers
- DOI
- 10.1016/j.ecl.2004.03.008
- PMID
- 15158528