Abstract
Methyl gallate (MG), methyl-3,4,5-trihydroxybenzoate, was highly active against herpes viruses as determined by plaque reduction assay. Herper simplex virus type 2, MS strain, was sensitive to MG at a mean 50% inhibitory concentration (IC50) of 0.224 μg/ml in monkey kidney cells. MG was specific for herpes viruses with the relative sensitivity HSV-2>HSV-1>CMV. Two RNA viruses tested were significantly less sensitive to MG. The structural components of MG which modulate the anti-herpetic activity were identified by analysis of chemical analogues. Our structural analyses indicated that three hydroxyl groups were required but were not sufficient for the anti-herpetic action of MG. The presence and chain length of the alkyl ester were also important to the anti-herpetic activity of MG. Methyl gallate may interact with virus proteins and alter the adsorption and penetration of the virion.
Keywords
Methyl gallateHerpes simplex virusGallateIn vitroChemistryVirusIC50Biological activityIn vivoVirologyBiochemistryStereochemistryMolecular biologyBiologyNuclear chemistryGallic acid
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Publication Info
- Year
- 1988
- Type
- article
- Volume
- 8
- Issue
- 1
- Pages
- 95-102
- Citations
- 70
- Access
- Closed
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Cynthia J.M. Kane,
Jay H. Menna,
Ching‐Ching Sung
et al.
(1988).
Methyl gallate, methyl-3,4,5-trihydroxybenzoate, is a potent and highly specific inhibitor of herpes simplex virus <i>in vitro</i>. II. Antiviral activity of methyl gallate and its derivatives.
Bioscience Reports
, 8
(1)
, 95-102.
https://doi.org/10.1007/bf01128976
Identifiers
- DOI
- 10.1007/bf01128976