Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

Robert J. Moore; David M. Owens; Gordon Stamp; Caroline H. Arnott; Frances Burke; N East; Hazel Holdsworth; Lynn Turner; Barrett J. Rollins; Manolis Pasparakis; George Kollias; Frances R. Balkwill

doi:10.1038/10552

Keywords

DMBATumor necrosis factor alphaCytokineCarcinogenesisTumor promotionKeratinocyteInflammationCancer researchTumor initiationDermisImmunologyChemokineCarcinogenBiologyMedicineCancerPathologyInternal medicineCell culture

Affiliated Institutions

Related Publications

Inhibitation of pro-inflammatory cytokine gene expression and papilloma growth during murine multistage carcinogenesis by pentoxifylline

Fredika M. Robertson , Michael S. Ross , Kathleen L. Tober +2 more

Topical application of 12-O-tetradecanoylphorbol-13-acetate (TPA) to the dorsal epidermis of Sencar mice induces synthesis of pro-inflammatory cytokines, including interleukin-1...

1996 Carcinogenesis 37 citations

Requirement for STAT1 in LPS-induced gene expression in macrophages

Yoshihiro Ohmori , Thomas A. Hamilton

Abstract This study examines the role of the signal transducer and activator of transcription 1 (STAT1) in induction of lipopolysaccharide (LPS)-stimulated gene expression both ...

2001 Journal of Leukocyte Biology 264 citations

IL-18 regulates IL-1<i>β</i>-dependent hepatic melanoma metastasis via vascular cell adhesion molecule-1

Fernando Vidal‐Vanaclocha , Giamila Fantuzzi , Lorea Mendoza +10 more

Proinflammatory cytokines, including IL-1 β and tumor necrosis factor- α (TNF- α ), promote cancer cell adhesion and liver metastases by up-regulating the expression of vascular...

2000 Proceedings of the National Academy o... 332 citations

Interleukin (IL)-1 Receptor–associated Kinase (IRAK) Requirement for Optimal Induction of Multiple IL-1 Signaling Pathways and IL-6 Production

Palanisamy Kanakaraj , Peter Schäfer , Druie Cavender +8 more

Interleukin (IL)-1 is a proinflammatory cytokine with pleiotropic effects in inflammation. IL-1 binding to its receptor triggers a cascade of signaling events, including activat...

1998 The Journal of Experimental Medicine 192 citations

Interleukin-1beta and tumor necrosis factor-alpha are expressed by different subsets of microglia and macrophages after ischemic stroke in mice

Bettina Hjelm Clausen , Kate Lykke Lambertsen , Alicia A. Babcock +3 more

Abstract Background Interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) are expressed by microglia and infiltrating macrophages following ischemic stroke. Whereas IL-1β i...

2008 Journal of Neuroinflammation 302 citations

Publication Info

Year: 1999
Type: article
Volume: 5
Issue: 7
Pages: 828-831
Citations: 829
Access: Closed

External Links

View on DOI.org

Social Impact

Altmetric

Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis

PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

829

OpenAlex

Cite This

APA Style

                            
                                
                                    Robert J. Moore, 
                                
                                    David M. Owens, 
                                
                                    Gordon Stamp
                                
                                et al.
                            
                            (1999). 
                            Mice deficient in tumor necrosis factor-α are resistant to skin carcinogenesis. 
                            Nature Medicine
                            , 5
                            (7)
                            , 828-831.
                            https://doi.org/10.1038/10552
                        

Identifiers

DOI: 10.1038/10552