miRBase: tools for microRNA genomics

Abstract

miRBase is the central online repository for microRNA (miRNA) nomenclature, sequence data, annotation and target prediction. The current release (10.0) contains 5071 miRNA loci from 58 species, expressing 5922 distinct mature miRNA sequences: a growth of over 2000 sequences in the past 2 years. miRBase provides a range of data to facilitate studies of miRNA genomics: all miRNAs are mapped to their genomic coordinates. Clusters of miRNA sequences in the genome are highlighted, and can be defined and retrieved with any inter-miRNA distance. The overlap of miRNA sequences with annotated transcripts, both protein- and non-coding, are described. Finally, graphical views of the locations of a wide range of genomic features in model organisms allow for the first time the prediction of the likely boundaries of many miRNA primary transcripts. miRBase is available at http://microrna.sanger.ac.uk/.

Keywords

MiRBaseBiologymicroRNAComputational biologyGenomicsGeneticsGenomeAnnotationSanger sequencingPersonal genomicsDNA sequencingGene

Affiliated Institutions

Wellcome Sanger Institute GB

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Publication Info

Year: 2007
Type: article
Volume: 36
Issue: Database
Pages: D154-D158
Citations: 4391
Access: Closed

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APA Style

                            
                                
                                    Sam Griffiths‐Jones, 
                                
                                    Harpreet K. Saini, 
                                
                                    Stijn van Dongen
                                
                                et al.
                            
                            (2007). 
                            miRBase: tools for microRNA genomics. 
                            Nucleic Acids Research
                            , 36
                            (Database)
                            , D154-D158.
                            https://doi.org/10.1093/nar/gkm952
                        

Identifiers

DOI: 10.1093/nar/gkm952