Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications

2011 Antioxidants and Redox Signaling 330 citations

Abstract

Recent technical progress in the identification and quantification of thiol modifications by redox proteomics means that many of the questions raised about the multiple roles of mitochondrial thiols can now be addressed.

Keywords

ThioredoxinGlutaredoxinPeroxiredoxinMitochondrial matrixMitochondrionGlutathioneBiochemistryThioredoxin reductaseOxidative stressThiolMethionine sulfoxide reductaseChemistryReactive oxygen speciesAntioxidantCell biologyOxidative phosphorylationBiologyPeroxidaseMethionineCytosolEnzymeAmino acid

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Publication Info

Year
2011
Type
review
Volume
16
Issue
6
Pages
476-495
Citations
330
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Michael P. Murphy (2011). Mitochondrial Thiols in Antioxidant Protection and Redox Signaling: Distinct Roles for Glutathionylation and Other Thiol Modifications. Antioxidants and Redox Signaling , 16 (6) , 476-495. https://doi.org/10.1089/ars.2011.4289

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DOI
10.1089/ars.2011.4289