Abstract
Breast cancers differ in response to treatment and may have a divergent clinical course despite having a similar histopathological appearance. New technology using DNA microarrays provides a systematic method to identify key markers for prognosis and treatment response by profiling thousands of genes expressed in a single cancer. Microarray profiling of 38 invasive breast cancers now confirms striking molecular differences between ductal carcinoma specimens and suggests a new classification for oestrogen-receptor negative breast cancer. Future approaches will need to include methods for high-throughput clinical validation and the ability to analyze microscopic samples.
Keywords
Breast cancerSurgical oncologyDNA microarrayMicroarrayMedicineGene expression profilingOncologyInternal medicineDuctal carcinomaBioinformaticsPathologyCancerBiologyGeneGene expressionGenetics
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Publication Info
- Year
- 2001
- Type
- review
- Volume
- 3
- Issue
- 2
- Pages
- 77-77
- Citations
- 34
- Access
- Closed
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Cite This
James D. Brenton,
Samuel Aparício,
Carlos Caldas
(2001).
Molecular profiling of breast cancer: portraits but not physiognomy..
Breast Cancer Research
, 3
(2)
, 77-77.
https://doi.org/10.1186/bcr274
Identifiers
- DOI
- 10.1186/bcr274