Monitoring of Blood Vessels and Tissues by a Population of Monocytes with Patrolling Behavior

Abstract

The cellular immune response to tissue damage and infection requires the recruitment of blood leukocytes. This process is mediated through a classical multistep mechanism, which involves transient rolling on the endothelium and recognition of inflammation followed by extravasation. We have shown, by direct examination of blood monocyte functions in vivo, that a subset of monocytes patrols healthy tissues through long-range crawling on the resting endothelium. This patrolling behavior depended on the integrin LFA-1 and the chemokine receptor CX 3 CR1 and was required for rapid tissue invasion at the site of an infection by this “resident” monocyte population, which initiated an early immune response and differentiated into macrophages.

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Affiliated Institutions

• Hôpital Necker-Enfants Malades FR
• Université Paris Cité FR
• Institut Necker Enfants Malades FR
• Institut de Pharmacologie Moléculaire et Cellulaire FR
• Assistance Publique – Hôpitaux de Paris FR
• Institut Pasteur FR
• Inserm FR
• Délégation Paris 5 FR

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