Abstract
Panel data are observations of a continuous-time process at arbitrary times, for example, visits to a hospital to diagnose disease status. Multi-state models for such data are generally based on the Markov assumption. This article reviews the range of Markov models and their extensions which can be fitted to panel-observed data, and their implementation in the <b>msm</b> package for R. Transition intensities may vary between individuals, or with piecewise-constant time-dependent covariates, giving an inhomogeneous Markov model. Hidden Markov models can be used for multi-state processes which are misclassified or observed only through a noisy marker. The package is intended to be straightforward to use, flexible and comprehensively documented. Worked examples are given of the use of <b>msm</b> to model chronic disease progression and screening. Assessment of model fit, and potential future developments of the software, are also discussed.
Keywords
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Publication Info
- Year
- 2011
- Type
- article
- Volume
- 38
- Issue
- 8
- Citations
- 1100
- Access
- Closed
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Identifiers
- DOI
- 10.18637/jss.v038.i08