Abstract

Though linked to an unusually broad array of functions, the human claustrum's complex morphology has hindered in vivo study, resulting in a small MRI literature marked by implausibly large discrepancies in reported characteristics. We constructed the first three-dimensional histological "gold standard" claustrum model, and systematically evaluated in vivo 7-Tesla MRI datasets against it and downsampled derivatives. MRI showed resolution-dependent differences rather than contrast limitations, transforming the claustrum's intricate sheet into an artefactually thickened ribbon. However, submillimetre MRI reliably recovered the dorsal "core" that contains most claustral volume and density and houses major corticoclaustral connectivity. At 0.5mm resolution, extension into the temporal lobe, including irregular ventral "puddles", was partially recovered, with uncertainty reflecting boundary imprecision rather than anatomical loss. Our results refute the view that the claustrum is inaccessible in the living human brain, define practical measurement limits, and provide a foundation for future functional investigations.

Related Publications

Publication Info

Year
2025
Type
article
Citations
0
Access
Closed

External Links

Download PDF (Free) View on DOI.org Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

0
OpenAlex
0
Influential
0
CrossRef

Cite This

Navona Calarco, Skerdi Progri, Sriranga Kashyap et al. (2025). Multiscale characterisation of the human claustrum from histology to MRI. . https://doi.org/10.64898/2025.12.06.692728

Identifiers

DOI
10.64898/2025.12.06.692728

Data Quality

Data completeness: 66%