Abstract
The origins of schizophrenia have eluded clinicians and researchers since Kraepelin and Bleuler began documenting their findings. However, large clinical research efforts in recent decades have identified numerous genetic and environmental risk factors for schizophrenia. The combined data strongly support the neurodevelopmental hypothesis of schizophrenia and underscore the importance of the common converging effects of diverse insults. In this review, we discuss the evidence that genetic and environmental risk factors that predispose to schizophrenia disrupt the development and normal functioning of the GABAergic system.
Keywords
Schizophrenia (object-oriented programming)PsychologyNeurosciencePsychiatrySchizophrenia researchPsychosisGABAergicClinical psychology
MeSH Terms
AnimalsBrainHumansReceptorsGABARisk FactorsSchizophreniagamma-Aminobutyric Acid
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Publication Info
- Year
- 2014
- Type
- review
- Volume
- 40
- Issue
- 1
- Pages
- 190-206
- Citations
- 221
- Access
- Closed
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Cite This
Martin Schmidt,
Károly Mirnics
(2014).
Neurodevelopment, GABA System Dysfunction, and Schizophrenia.
Neuropsychopharmacology
, 40
(1)
, 190-206.
https://doi.org/10.1038/npp.2014.95
Identifiers
- DOI
- 10.1038/npp.2014.95
- PMID
- 24759129
- PMCID
- PMC4262918