Abstract

Three new labdane diterpenes, 12 alpha,17-epoxy-3 beta-hydroxy-8(9),13- labdadien-16,15-olide (aulacocarpinolide) [1], methyl 8 beta,17:14 zeta,15-diepoxy-3 beta-hydroxy- 12E-labden-16-oate (aulacocarpin A) [2], and methyl 8 beta,17:14 zeta,15-diepoxy-3 beta,6 beta- dihydroxy-12E-labden-16-oate (aulacocarpin B) [3] have been isolated from the Cameroonian spice, Aframomum aulacocarpos, and their structures elucidated using spectroscopic techniques. The known bioactive diterpene dialdehyde, 8 beta,17-epoxy-12E-labdene-15,16-dial (aframodial) [4] was also isolated. Compounds 1-3 showed weak antimicrobial and cytotoxic activities.

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Publication Info

Year
1994
Type
article
Volume
57
Issue
7
Pages
917-923
Citations
69
Access
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J. Foyere Ayafor, Marguerite H. K. Tchuendem, Barthélemy Nyasse et al. (1994). Novel Bioactive Diterpenoids from Aframomum aulacocarpos. Journal of Natural Products , 57 (7) , 917-923. https://doi.org/10.1021/np50109a007

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DOI
10.1021/np50109a007