Abstract
Drosophila photoreceptors are excellent models for studies of the ubiquitous phosphoinositide signalling cascade. Recent studies suggest that light-induced phosphoinositide hydrolysis in Drosophila leads to the activation of two classes of channels. One is selective for Ca2+ and absent in the transient receptor potential mutant trp. The trp gene product, which shows some structural similarity to vertebrate voltage-gated Ca2+ channels, may thus define a novel family of second-messenger-operated Ca2+ channels generally responsible for the widespread but poorly understood phenomenon of phosphoinositide-mediated Ca2+ entry. The other channel is a non-selective cation channel that requires Ca2+ for activation. As well as being a major charge carrier for the light-induced current, Ca2+ influx via the trp-dependent channels appears to be required for refilling Ca2+ stores sensitive to inositol 1,4,5-trisphosphate and for feedback regulation (light adaptation) of the transduction cascade.
Keywords
Transient receptor potential channelCell biologyTransduction (biophysics)BiologyIon channelSecond messenger systemInositol trisphosphateSignal transductionReceptor potentialNeuroscienceCalcium signalingInositolInositol trisphosphate receptorBiophysicsChemistryReceptorBiochemistry
MeSH Terms
AnimalsCalciumCalcium ChannelsDrosophilaPhosphatidylinositolsPhotoreceptor CellsInvertebrateSignal Transduction
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Publication Info
- Year
- 1993
- Type
- review
- Volume
- 16
- Issue
- 9
- Pages
- 371-376
- Citations
- 257
- Access
- Closed
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Cite This
Roger Hardie,
Baruch Minke
(1993).
Novel Ca2+ channels underlying transduction in Drosophila photoreceptors: implications for phosphoinositide-mediated Ca2+ mobilization.
Trends in Neurosciences
, 16
(9)
, 371-376.
https://doi.org/10.1016/0166-2236(93)90095-4
Identifiers
- DOI
- 10.1016/0166-2236(93)90095-4
- PMID
- 7694408