Abstract

The transcription factor NRF2 is the master regulator of the cellular antioxidant response. Though recognized originally as a target of chemopreventive compounds that help prevent cancer and other maladies, accumulating evidence has established the NRF2 pathway as a driver of cancer progression, metastasis, and resistance to therapy. Recent studies have identified new functions for NRF2 in the regulation of metabolism and other essential cellular functions, establishing NRF2 as a truly pleiotropic transcription factor. In this review, we explore the roles of NRF2 in the hallmarks of cancer, indicating both tumor suppressive and tumor-promoting effects.

Keywords

Transcription factorBiologyMetastasisRegulatorCancer cellCancerCancer researchBioinformaticsGeneticsGene

MeSH Terms

AnimalsCell MovementCell ProliferationCell TransformationNeoplasticDrug ResistanceNeoplasmGene Expression RegulationNeoplasticHumansNF-E2-Related Factor 2Neoplasm MetastasisNeoplasmsSignal Transduction

Affiliated Institutions

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Publication Info

Year
2018
Type
review
Volume
34
Issue
1
Pages
21-43
Citations
1516
Access
Closed

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Cite This

Montserrat Rojo de la Vega, Eli Chapman, Donna D. Zhang (2018). NRF2 and the Hallmarks of Cancer. Cancer Cell , 34 (1) , 21-43. https://doi.org/10.1016/j.ccell.2018.03.022

Identifiers

DOI
10.1016/j.ccell.2018.03.022
PMID
29731393
PMCID
PMC6039250

Data Quality

Data completeness: 90%