Abstract

Maternal obesity is associated with increased morbidity and mortality for both mother and offspring. The mechanisms underlying the increased risk associated with maternal obesity are not well understood. In non-pregnant populations, many of the complications of obesity are thought to be mediated in part by inflammation and its sequelae. Recent studies suggest that a heightened inflammatory response may also be involved in mediating adverse clinical outcomes during pregnancy. This review summarizes our current knowledge about adipose tissue biology, and its role as an endocrine and inflammatory organ. The evidence for inflammation as a key mediator of adverse pregnancy outcome is also presented, focusing on the role of inflammation in adipose tissue, systemic inflammation, the placenta, and vascular endothelium.

Keywords

InflammationAdipose tissuePregnancyObesityMedicineOffspringEndocrine systemPlacentaBioinformaticsMediatorPhysiologyFetusImmunologyInternal medicineBiologyHormone

MeSH Terms

Adipose TissueEndotheliumVascularFemaleFibrinolysisHumansInflammationInflammation MediatorsObesityPregnancyPregnancy ComplicationsPregnancy ComplicationsCardiovascularPregnancy OutcomeRisk Factors

Affiliated Institutions

Related Publications

Publication Info

Year
2010
Type
article
Volume
140
Issue
3
Pages
373-385
Citations
214
Access
Closed

External Links

Download PDF (Free) View on DOI.org PubMed Semantic Scholar

Social Impact

Altmetric
PlumX Metrics

Social media, news, blog, policy document mentions

Citation Metrics

214
OpenAlex
10
Influential
173
CrossRef

Cite This

Fiona C. Denison, Kirsty Roberts, SM Barr et al. (2010). Obesity, pregnancy, inflammation, and vascular function. Reproduction , 140 (3) , 373-385. https://doi.org/10.1530/rep-10-0074

Identifiers

DOI
10.1530/rep-10-0074
PMID
20215337

Data Quality

Data completeness: 86%