Abstract
Protein-tyrosine kinases (PTKs) are important regulators of intracellular signal-transduction pathways mediating development and multicellular communication in metazoans. Their activity is normally tightly controlled and regulated. Perturbation of PTK signalling by mutations and other genetic alterations results in deregulated kinase activity and malignant transformation. The lipid kinase phosphoinositide 3-OH kinase (PI(3)K) and some of its downstream targets, such as the protein-serine/threonine kinases Akt and p70 S6 kinase (p70S6K), are crucial effectors in oncogenic PTK signalling. This review emphasizes how oncogenic conversion of protein kinases results from perturbation of the normal autoinhibitory constraints on kinase activity and provides an update on our knowledge about the role of deregulated PI(3)K/Akt and mammalian target of rapamycin/p70S6K signalling in human malignancies.
Keywords
KinaseCell biologyc-RafProtein kinase BSignal transductionBiologyASK1MAP2K7EffectorMAP kinase kinase kinaseReceptor tyrosine kinaseProtein kinase AChemistryMitogen-activated protein kinase kinaseCyclin-dependent kinase 2
MeSH Terms
AnimalsHumansMutationNeoplasmsOncogene Protein v-aktOncogene ProteinsOncogenesPhosphatidylinositol 3-KinasesProtein-Tyrosine KinasesReceptor Protein-Tyrosine KinasesRetroviridae ProteinsOncogenicRibosomal Protein S6 KinasesSignal Transduction
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Publication Info
- Year
- 2001
- Type
- review
- Volume
- 411
- Issue
- 6835
- Pages
- 355-365
- Citations
- 3672
- Access
- Closed
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Cite This
Peter Blume‐Jensen,
Tony Hunter
(2001).
Oncogenic kinase signalling.
Nature
, 411
(6835)
, 355-365.
https://doi.org/10.1038/35077225
Identifiers
- DOI
- 10.1038/35077225
- PMID
- 11357143