Abstract
During inflammatory processes biologically active lipid oxidation products accumulate that modulate the inflammatory process and may determine the fate and outcome of the body's reaction in acute inflammation during host defense. Oxidized phospholipids may induce and propagate chronic inflammatory processes; however, evidence is accumulating that cells and tissues respond towards these oxidatively formed stress signals also by activation of anti-inflammatory, cytoprotective reactions.
Keywords
InflammationLipopolysaccharideChemistryTumor necrosis factor alphaImmune systemSignal transductionCell biologyPhospholipidLipid signalingBiochemistryBiologyImmunology
Affiliated Institutions
Related Publications
Reactive Oxygen Species in Metabolic and Inflammatory Signaling
Reactive oxygen species (ROS) are well known for their role in mediating both physiological and pathophysiological signal transduction. Enzymes and subcellular compartments that...
Identification of Renox, an NAD(P)H oxidase in kidney
Oxygen sensing is essential for homeostasis in all aerobic organisms, but its mechanism is poorly understood. Data suggest that a phagocytic-like NAD(P)H oxidase producing react...
Publication Info
- Year
- 2003
- Type
- review
- Volume
- 14
- Issue
- 5
- Pages
- 421-430
- Citations
- 289
- Access
- Closed
External Links
Social Impact
Altmetric
PlumX Metrics
Social media, news, blog, policy document mentions
Citation Metrics
289
OpenAlex
Cite This
Norbert Leitinger
(2003).
Oxidized phospholipids as modulators of inflammation in atherosclerosis.
Current Opinion in Lipidology
, 14
(5)
, 421-430.
https://doi.org/10.1097/00041433-200310000-00002
Identifiers
- DOI
- 10.1097/00041433-200310000-00002